Mechanochemical coupling in the myosin motor domain. I. Insights from equilibrium active-site simulations.
Although the major structural transitions in molecular motors are often argued to Container Set couple to the binding of Adenosine triphosphate (ATP), the recovery stroke in the conventional myosin has been shown to be dependent on the hydrolysis of ATP.To obtain a clearer mechanistic picture for such "mechanochemical coupling" in myosin, equilibri